After the disastrous food storm in the first film, Flint and his friends are forced to leave the town. Flint accepts the invitation from his idol Chester V to join The Live Corp Company, which has been tasked to clean the island, and where the best inventors in the world create technologies for the betterment of mankind. When Flint discovers that his machine still operates and now creates mutant food beasts like living pickles, hungry tacodiles, shrimpanzees and apple pie-thons, he and his friends must return to save the world.
Flint Lockwood now works at The Live Corp Company for his idol Chester V. But he's forced to leave his post when he learns that his most infamous machine is still operational, and is churning out menacing food-animal hybrids.