In need of creative inspiration, a professionally stagnant and hard-partying Los Angeles artist recklessly indulges in a series of drug binges. As the narcotics fly out of control, so does her newfound and inexplicable, yet unquenchable, craving for blood.
A mind-bending love story following Greg who, after recently being divorced and then fired, meets the mysterious Isabel, a woman living on the streets and convinced that the polluted, broken world around them is a computer simulation.