In eighteenth century Romania, Rayne, a dhampir (half-human, half-vampire), prone to fits of blind blood rage but saddled with a compunction for humans, strives to avenge her mother's rape by her father, Kagan, King of Vampires. Two vampire hunters, Sebastian and Vladimir, from the Brimstone Society persuade her to join their cause.
In the eighteenth century, a vampire escapes from the freak show, in which she once participated, and teams up with a group of vampire slayers to kill the man who raped her mother.