Liz and the Task Force investigate an infamous assassin who has a long history of weaponizing diseases, but has now turned to even more insidious activities. Red and Dembe travel to Cuba in search of a lead. Aram considers a new relationship.
A new FBI profiler, Elizabeth Keen, has her entire life uprooted when a mysterious criminal, Raymond Reddington, who has eluded capture for decades, turns himself in and insists on speaking only to her.