Famed monster slayer Gabriel Van Helsing (Hugh Jackman) is dispatched to Transylvania to assist the last of the Valerious bloodline in defeating Count Dracula. Anna Valerious (Kate Beckinsale) reveals that Dracula has formed an unholy alliance with Dr. Frankenstein's monster and is hell-bent on exacting a centuries-old curse on her family.
The famed monster hunter is sent to Transylvania to stop Count Dracula, who is using Dr. Frankenstein's research and a werewolf for nefarious purposes.