Crimes of the Future is set in a future where sexually mature woman appear to have been obliterated by a plague produced by the use of cosmetics. It details the wanderings of Adrian Tripod director of the dermatological clinic the House of Skin. Tripod seems at a loss following the disappearance of his mentor Antoine Rouge.
In a dystopic world where a plague is killing off pubescent human females, an esoteric researcher seeks his missing mentor while trying to retain morality in the sex-obsessed society he lives in.