As the city is locked down under quarantine, Alice joins a small band of elite soldiers, enlisted to rescue the missing daughter of the creator of the mutating T-virus. It's a heart-pounding race against time as the group faces off against hordes of blood- thirsty zombies, stealthy Lickers, mutant canines and the most sinister foe yet.
Alice wakes up in the Raccoon City hospital after the area has been overrun by zombies, and must now make it out of the city before a nuclear bomb is dropped.