Drowning his sorrows after that botched mission during World War II, the traumatized ex-fighter pilot with a neurotic fear of flying, Ted Striker, still has not got over his old flame and flight attendant, Elaine Dickinson. Determined to win her back, Ted boards a domestic flight from Los Angeles to Chicago, only to come face-to-face with a severe case of in-flight food poisoning that is threatening everyone's lives. Now, with most of the passengers and the entire cockpit crew down with the food-borne illness, Striker has no other choice but to confront his inner demons and take over the control of the ungovernable aircraft with the help of a gruff air-traffic controller and his former commander. Can Ted Striker land the airplane and save the passengers?—Nick Riganas