Crawldaddy and her two kids have been travelling cross-country selling fine leather apparel, when their van breaks down in a small town in Ohio. Tom and his wife decide to put them up for the weekend. However, their neighbor Paul, a disturbed ex-cop and a drunk, discovers that Crawldaddy's dysfunctional backwoods family has been killing people and skinning them alive to make their leather goods! Crawldaddy and her kids continue to find victims while fighting amongst each other (utilizing an impressive combination of vulgar yet hilarious insults), meanwhile Paul's personal life spirals out of control. It all builds to a final climactic confrontation.