Los Angeles advertisement director Max visits his friend, artist Charlie, who was diagnosed with A.I.D.S. in New York City. There he meets Karen, they are attracted to each other and after they meet later that day at the concert, they have a passionate night. Then he returns home to Los Angeles to his family, and wife Mimi. A year later, Max returns to New York City again to visit Charlie, who is now dying, and there he meets Karen again, who is married to Charlie's brother Vernon.
Max/W.Snipes has a one night stand with Karen/N.Kinski in NYC. He returns to his wife, 2 kids and career in LA but is affected. A year later, Max and Karen meet again by chance, but this time they're with their spouses.