Textbook in PDF format Focusing on basic theory, emerged technologies and underlying engineering solutions, we investigate frontiers of engineering and science in design and control of physical and cyber-physical systems (CPS). Advanced-technology multi-physics systems are designed by seamlessly integrating components and modules, guaranteeing overall specifications and functionality by means of data processing, management and control. Analog and digital controllers and data management are implemented by analog and mixed-signal ASICs, as well as by microcontrollers and field-programmable gate arrays. Cybersecurity and information security have become critical